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  <link:calculationLink xlink:role="http://www.exagen.com/role/FairValueMeasurementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_68627cd2-a738-4b3a-8979-2557cd1af9fd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_4e5639ba-6042-40ab-a49d-06d6a66bc5c7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_68627cd2-a738-4b3a-8979-2557cd1af9fd" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_4e5639ba-6042-40ab-a49d-06d6a66bc5c7" xlink:type="arc"/>
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</link:linkbase>
